Produção Nacional
Revisado por pares
Analgesic and Anti-Inflammatory Activities of the Isomeric Mixture of Alpha- and Beta-Amyrin from Protium heptaphyllum(Aubl.) March
2008; Taylor & Francis; Volume: 7; Issue: 2 Linguagem: Inglês
10.1300/j157v07n02_03
ISSN1522-9106
AutoresGislei Frota Aragão, Marta Cristhiany Cunha Pinheiro, Paulo Nogueira Bandeira, Telma L. G. Lemos, Glauce de Barros Viana,
Tópico(s)Pharmacological Effects of Natural Compounds
ResumoIn the present work, we demonsteated that the mixture of alpha- and beta-amyrin (AMI) from Protium heptaphyllum has anti-nociceptive activity as was evident from the writhing and formalin tests in mice. AMI (10 and 50 mg/kg, i.p.) inhibited writhing in 73 and 94%, respectively, while preferentially inhibiting the 2nd phase of the response (37 and 51; and 60 and 73% inhibitions of the 1st and 2nd phases, respectively) to the formalin test. Naloxone, an opioid antagonist, did not reverse the antinociceptive effect. AMI (50 mg/kg, i.p.) was also active in the hot plate test, increasing the reaction time to thermal stimulus after 30 and 60 min, by 62 and 71%, respectively. A preventive antiedematogenic effect was observed in mice that had a carrageenan-in-duced paw edema. Paw volume was significantly and dose-dependently decreased by 39,42 and 53%, three hours after administration of 10, 25 and 50 mg/kg doses, i.p., respectively. AMI (25 and 50 mg/kg, i.p.) was also able to reverse the edema already induced by carrageenan (curative effect). AMI (10 and 25 mg/kg, i.p.) was equally effective in the dex-tran-induced paw edema (preventive effect), reducing the paw volume by 50 and 60% at the 2nd hour, and by 63 and 73% at the third hour post-dose. AMI (50 mg/kg, i.p.) reverted the edema already formed after the dextran injection (curative effect). In conclusion, AMI demonstrated peripheral and central analgesic effects independent of the opioid system, and also showed a potent anti-inflammatory activity. The anti-inflammatory activity was potentiated by both indomethacin and thalid-omide, suggesting a potential involvement of prostaglandins and TNF-alpha inhibitions.
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