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A powder made from seeds and shells of a rose‐hip subspecies ( Rosa canina ) reduces symptoms of knee and hip osteoarthritis: a randomized, double‐blind, placebo‐controlled clinical trial

2005; Taylor & Francis; Volume: 34; Issue: 4 Linguagem: Inglês

10.1080/03009740510018624

1502-7732

K. Winther, Klaus Apel, Gorm Thamsborg,

Inflammatory mediators and NSAID effects

AbstractObjective: The aim of this study was to determine whether a herbal remedy made from a subspecies of rose‐hip (Rosa canina) might reduce symptoms of osteoarthritis and consumption of rescue medication in patients suffering from osteoarthritis.Methods: Ninety‐four patients with osteoarthritis of the hip or knee were enrolled in a randomized, placebo‐controlled, double‐blind crossover trial. Forty‐seven patients were given 5 g of the herbal remedy daily for a period of 3 months and the remaining patients were given a similar amount of placebo. The group initially treated with placebo was then changed to rose‐hip and vice versa for another 3‐month period. Upon inclusion and after 3 weeks and 3 months of each treatment period, pain, stiffness, disability, and global severity of the disease were scored on a Western Ontario and McMaster Universities (WOMAC) questionnaire. After 3 weeks of treatment, patients, if possible, were allowed to reduce their consumption of 'rescue medication'. Data were analysed on the basis of intention to treat.Results: Rose‐hip resulted in a significant reduction in WOMAC pain (p<0.014) as compared to placebo, when testing after 3 weeks of treatment. The consumption of 'rescue medication' significantly declined as a result of active treatment (p<0.027). WOMAC disability, stiffness, and global assessment of severity of the disease were not altered by 3 weeks but decreased significantly (p<0.018, p<0.038, and p<0.035, respectively) after 3 months of treatment.Conclusion: The data suggest that the present herbal remedy can alleviate symptoms of osteoarthritis and reduce the consumption of 'rescue medication'.