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BIBTEX RIS

Failure of CDKN2A/B ( INK4A/B–ARF )-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL

2008; Cold Spring Harbor Laboratory Press; Volume: 22; Issue: 11 Linguagem: Inglês

10.1101/gad.1673908

ISSN

1549-5477

Autores

Charles G. Mullighan, Richard T. Williams, James R. Downing, Charles J. Sherr,

Tópico(s)

Acute Myeloid Leukemia Research

Resumo

Deletions of the CDKN2A/B tumor suppressor locus and of the IKAROS and PAX5 genes that promote B-lineage development occur frequently in lymphoid, but not myeloid leukemias initiated by the BCR-ABL tyrosine kinase. Why is this the case, and how do these genetic lesions contribute to an aggressive disease that fails to durably respond to targeted kinase inhibitors?

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