Portal de Periódicos da CAPES

OTOF mutations revealed by genetic analysis of hearing loss families including a potential temperature sensitive auditory neuropathy allele

2005; BMJ; Volume: 43; Issue: 7 Linguagem: Inglês

10.1136/jmg.2005.038612

1468-6244

Renée Varga, Matthew R. Avenarius, Philip M. Kelley, Bronya J.B. Keats, Charles I. Berlín, Linda J. Hood, Thierry Morlet, Shanda Brashears, Arnold Starr, Edward Cohn, Richard J. Smith, W. J. Kimberling,

Vestibular and auditory disorders

The majority of hearing loss in children can be accounted for by genetic causes. Non-syndromic hearing loss accounts for 80% of genetic hearing loss in children, with mutations in DFNB1/GJB2 being by far the most common cause. Among the second tier genetic causes of hearing loss in children are mutations in the DFNB9/OTOF gene.