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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

IDH1 mutations in a Brazilian series of Glioblastoma

2011; Elsevier BV; Volume: 66; Issue: 1 Linguagem: Inglês

10.1590/s1807-59322011000100028

ISSN

1980-5322

Autores

Miyuki Uno, Sueli Mieko Oba‐Shinjo, Roseli da Silva, Flávio Key Miura, Carlos Clara, J.R.W. Almeida, Suzana Mária Fleury Malheiros, A Bianco, Reynaldo André Brandt, Guilherme Carvalhal Ribas, Halim Feres, Carlos Dzik, Sérgio Rosemberg, João Norberto Stávale, Manoel Jacobsen Teixeira, Suely Kazue Nagahashi Marie,

Tópico(s)

Pancreatic and Hepatic Oncology Research

Resumo

GBM may manifest rapidly de novo(primary GBM), or may develop slowly from grade II orgrade III astrocytomas (secondary GBM), suggesting thatthey are distinct disease entities that evolve throughdifferent genetic pathways.In recent genome-wide analyses, high rates of sponta-neous mutations in the gene encoding cytosolic NADP-dependent isocitrate dehydrogenase 1 (IDH1) have beenreported in diffuse gliomas including WHO grades II andIII astroglial and oligodendroglial lineages.

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