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Prevalence and genetic characterisation of HTLV-1 and 2 dual infections in patients with pulmonary tuberculosis in Central-West Brazil

2014; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 109; Issue: 1 Linguagem: Inglês

10.1590/0074-0276130230

1678-8060

Aline Garcia Kozlowski, Megmar Aparecida dos Santos Carneiro, Márcia Alves Dias de Matos, Sheila Araújo Teles, João Alves Araújo Filho, Koko Otsuki, Ana Carolina Paulo Vicente, Regina Maria Bringel Martins,

Vector-Borne Animal Diseases

Human T-cell lymphotropic virus (HTLV) may impact the clinical course of tuberculosis (TB). Both infections are highly endemic in Brazil. The aim of this study was to assess the prevalence of HTLV-1/2 in TB patients in Central-West Brazil and to perform a genetic characterisation of the respective isolates. Of the 402 patients, six (1.49%) were positive for anti-HTLV and five (1.24%; 95% confidence interval: 0.46-3.05) were infected with HTLV-1/2. Genetic characterisation demonstrated that the four HTLV-1 isolates belonged to the Transcontinental subgroup A of the Cosmopolitan subtype a and that the HTLV-2 isolate belonged to subtype a (HTLV-2a/c). The prevalence of HTLV infection observed in this study is higher than that observed in local blood donors and the HTLV-1 and 2 subtypes identified are consistent with those circulating in Brazil.