Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir

2013; Oxford University Press; Volume: 209; Issue: 5 Linguagem: Inglês

10.1093/infdis/jit562

ISSN

1537-6613

Autores

Xiao Tong, Sophie Le Pogam, Lewyn Li, Kristin Haines, Katherine Piso, Victoria A. Baronas, Junmei Yan, Sung‐Sau So, Klaus Klumpp, Isabel Nájera,

Tópico(s)

Biochemical and Molecular Research

Resumo

Background. Resistance to mericitabine (prodrug of HCV NS5B polymerase inhibitor PSI-6130) is rare and conferred by the NS5B S282T mutation.

Referência(s)