Produção Nacional
O efeito da sibutramina na perda de peso de adolescentes obesos
2014; Editora da Universidade de São Paulo; Volume: 58; Issue: 3 Linguagem: Inglês
10.1590/0004-2730000002825
ISSN1677-9487
AutoresRuth Rocha Franco, Louise Cominato, Durval Damiani,
Tópico(s)Muscle metabolism and nutrition
ResumoTo evaluate the effect of sibutramine on weight loss in obese adolescents.A double-blind controlled study lasting 13 months. The study included 73 obese adolescents of both sexes aged between 10 and 18 years. Laboratory tests and imaging studies were performed before, during wash-out, and at the end of 13 months.The percentage of patients who lost 10% of their initial weight in the placebo group was 46%, and in the sibutramine group was 75%. When placebo was used, average weight rose by 1.61 kg, and BMI decreased by 0.24 kg/m(2) whereas with the use of sibutramine, weight decreased by 4.47 kg, and average BMI decreased, 2.38 kg/m(2), with p < 0.001.Sibutramine induced significantly more weight loss in obese adolescents compared with placebo, without significant side effects. The weight loss curve was different depending on the moment sibutramine was introduced. This finding indicates that the best time to start sibutramine is when adhesion begins to fail.
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