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High Rate of HIV Resuppression After Viral Failure on First-line Antiretroviral Therapy in the Absence of Switch to Second-line Therapy

2013; Oxford University Press; Volume: 58; Issue: 7 Linguagem: Inglês

10.1093/cid/cit933

1537-6591

Ravindra K. Gupta, Ruth Goodall, M. Ranopa, Cissy Kityo, Paula Munderi, Fred Lyagoba, Lincoln Mugarura, Charles F. Gilks, Pontiano Kaleebu, Deenan Pillay, Heiner Grosskurth, Paula Munderi, Geoffrey Kabuye, D. Nsibambi, Ronnie Kasirye, E. Zalwango, M. Nakazibwe, Bernard Kikaire, G. Nassuna, R. Massa, K. Fadhiru, M. Namyalo, Aisha Zalwango, L. Generous, P. Khauka, N. Rutikarayo, W. Nakahima, Apollo Mugisha, Jim Todd, Jonathan Levin, Sylvia Kiwuwa Muyingo, Anthony Ruberantwari, Pontiano Kaleebu, David Yirrell, N. Ndembi, Fred Lyagoba, Peter J. Hughes, M. Aber, A. Medina Lara, Scott A. Foster, Jovita Amurwon, Peter Mugyenyi, Cissy Kityo, Francis Ssali, D. Tumukunde, T. Otim, Joseph Kabanda, Hellen Musana, Juliet Akao, Hope Kyomugisha, Adolf Byamukama, J. Sabiiti, J. Komugyena, Priscilla Wavamunno, S. Mukiibi, Amos Drasiku, R Byaruhanga, O. Labeja, Pauline Katundu, S. Tugume, P. Awio, A. Namazzi, T. G. Bakeinyaga, H. Katabira, D. Abaine, J Tukamushaba, W. Anywar, W. Ojiambo, E. Angweng, S. Murungi, W. Haguma, S. Atwiine, Joanita Kigozi, Ahmed Latif, James Hakim, Val J. Robertson, Andrew Reid, Ennie Chidziva, R. Bulaya-Tembo, Godfrey Musoro, Fabian Taziwa, Cleophas Chimbetete, L. Chakonza, A. Mawora, C. Muvirimi, G Tinago, P. Svovanapasis, M. Simango, O. Chirema, J. Machingura, S Mutsai, Mwelwa Phiri, T Bafana, M. Chirara, Lazarus Muchabaiwa, M. Muzambi, Elly Katabira, Allan Ronald, A. Kambungu, Fred Lutwama, A. Nanfuka, J Walusimbi, Evelyn Nabankema, R. Nalumenya, T. Namuli, R. Kulume, I. Namata, L. Nyachwo, A. Florence, A. Kusiima, E Lubwama, R. Nairuba, F. Oketta, E Buluma, R. Waita, Henry Ojiambo, F. Sadik, J Wanyama, P. Nabongo, Robert Ochai, D. Muhweezi, Charles F. Gilks, K. Boocock, C. Puddephatt, D. Winogron, J. Kyle Bohannon, J. Darbyshire, M. D. Gibb, Andy Burke, D. Bray, AG Babiker, Sarah Walker, H Wilkes, Mary Rauchenberger, S. Sheehan, Leon Peto, Kirk A. Taylor, Moira J. Spyer, Alexander Ferrier, B. Naidoo, David Dunn, Ruth Goodall, R. Nanfuka, C. Mufuka-Kapuya, Pontiano Kaleebu, Deenan Pillay, P. Awio, M. Chirara, David Dunn, Charles F. Gilks, Ruth Goodall, Anne Kapaata, M. Katuramur, Fred Lyagoba, Rose Magala, Brian Magambo, K. Mataruka, Adele McCormick, Lincoln Mugarura, T. Musunga, M. Nabankkema, Jonathan Nkalubo, Peter Nkurunziza, Chris M. Parry, Val J. Robertson, Moira J. Spyer, David Yirrell, A. Medina Lara, Scott A. Foster, Jovita Amurwon, B. Nyanzi Wakholi, Joanita Kigozi, Lazarus Muchabaiwa, M. Muzambi, Ian Weller, AG Babiker, Silver Bahendeka, Mary T. Bassett, A. Chogo Wapakhabulo, J. Darbyshire, B Gazzard, Charles F. Gilks, James Hakim, Ahmed Latif, C. Mapuchere, Owen Mugurungi, Peter Mugyenyi, Corey Burke, Samuel Adeniyi Jones, C.J. Newland, S Rahim, James F. Rooney, M. Kumi Smith, Wendy Snowden, J.-M. Steens, AM Breckenridge, Anya T. McLaren, C. Hill, Jonathan Matenga, Anton Pozniak, David Serwadda, Tim Peto, Adrian Palfreeman, Margaret Borok,

HIV Research and Treatment

In a randomized comparison of nevirapine or abacavir with zidovudine plus lamivudine, routine viral load monitoring was not performed, yet 27% of individuals with viral failure at week 48 experienced resuppression by week 96 without switching. This supports World Health Organization recommendations that suspected viral failure should trigger adherence counseling and repeat measurement before a treatment switch is considered.