The natriuretic-peptide family
1997; Elsevier BV; Volume: 349; Issue: 9061 Linguagem: Inglês
10.1016/s0140-6736(96)07424-7
ISSN1474-547X
AutoresMartin R. Wilkins, Juliana Redondo, Lesley A. Brown,
Tópico(s)Potassium and Related Disorders
ResumoThe discovery in the early 1980s of atrial natriuretic peptide, a circulating peptide with natriuretic/diuretic and vasorelaxant properties was greeted with excitement since the existence of a humoral link between heart and kidney had long been predicted. A multidisciplinary investigation of atrial natriuretic peptide raised expectations of new insights into the pathogenesis of cardiovascular and renal disease and opportunities for the regulation of salt and water excretion and blood pressure. What progress has been made?
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