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Tumor Necrosis Factor (TNF-α) and C-reactive Protein (CRP) are Positively Associated with the Risk of Chronic Kidney Disease in Patients with Type 2 Diabetes

2010; Yonsei University College of Medicine; Volume: 51; Issue: 4 Linguagem: Inglês

10.3349/ymj.2010.51.4.519

1976-2437

Eun‐Sil Yeo, Ji‐Yun Hwang, Ji Eun Park, Young Ju Choi, Kap Bum Huh, Wha Young Kim,

Healthcare cost, quality, practices

The prevalence of type 2 diabetes has been rapidly rising worldwide.In Korea, the prevalence of diabetes (95% of which were cases of type 2 diabetes) has increased from 1% of the general population in the 1970s to 13.5% of men and 10.7% of women aged 30 years or more in 2000. 1 Chronic kidney disease (CKD) is one of the major complications of type 2 diabetes, and is the leading cause of endstage renal disease (ESRD), accounting for approximately 40% of new cases of ESRD every year. 2 Early detection and treatment of CKD in patients with type 2 diabetes can prevent or retard the progression to ESRD.Several studies have reported positive associations between inflammatory biomarkers and ESRD 3-5 or advanced kidney failure. 6However, few studies have