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Hypothalamo-pituitary-adrenal function in intrinsic non-atopic asthma.

1975; BMJ; Volume: 30; Issue: 5 Linguagem: Inglês

10.1136/thx.30.5.578

1468-3296

J.V. Collins, David Bellamy, Mark Britton, James T. Townsend, DONA BROWN,

Asthma and respiratory diseases

Sixteen patients with intrinsic non-atopic asthma with persistent wheezing who had never been treated with corticosteroids showed normal adrenocortical responses to prolonged stimulation with Tetracosactin Depot. In a subgroup of six patients the hypothalamo-pituitary-adrenal (HPA) response to a standard insulin stress test was normal. It is concluded that impaired responsiveness of the HPA axis is unlikely to be a common factor in initiating or maintaining airways obstruction in patients with intrinsic asthma.