Portal de Periódicos da CAPES

Identification of natural killer cells in human atherosclerotic plaque

2005; Elsevier BV; Volume: 180; Issue: 2 Linguagem: Inglês

10.1016/j.atherosclerosis.2005.01.046

1879-1484

Yuri V. Bobryshev, Reginald S. A. Lord,

T-cell and B-cell Immunology

The adaptive and innate immune systems have been implemented in atherogenesis [ 1 Hansson G.K. Immune mechanisms in atherosclerosis. Arterioscler Thromb Vasc Biol. 2001; 21: 1876-1890 Crossref PubMed Scopus (735) Google Scholar , 2 Hansson G.K. Libby P. Schonbeck U. Yan Z.Q. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002; 91: 281-291 Crossref PubMed Scopus (869) Google Scholar ]. Inflammatory infiltrates in atherosclerotic plaques contain macrophages, activated T cells and dendritic cells [ 1 Hansson G.K. Immune mechanisms in atherosclerosis. Arterioscler Thromb Vasc Biol. 2001; 21: 1876-1890 Crossref PubMed Scopus (735) Google Scholar , 2 Hansson G.K. Libby P. Schonbeck U. Yan Z.Q. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002; 91: 281-291 Crossref PubMed Scopus (869) Google Scholar , 3 Bobryshev Y.V. Dendritic cells and their involvement in atherosclerosis. Curr Opin Lipidol. 2000; 11: 511-517 Crossref PubMed Scopus (74) Google Scholar ]. Recent studies utilizing mouse models [ 4 Schiller N.K. Boisvert W.A. Curtiss L.K. Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst (beige) mutations. Arterioscler Thromb Vasc Biol. 2002; 22: 1341-1346 Crossref PubMed Scopus (50) Google Scholar , 5 Whitman S.C. Rateri D.L. Szilvassy S.J. Yokoyama W. Daugherty A. Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice. Arterioscler Thromb Vasc Biol. 2004; 24: 1049-1054 Crossref PubMed Scopus (125) Google Scholar ] indicate that natural killer (NK) cells play a role in atherosclerosis as well [ 4 Schiller N.K. Boisvert W.A. Curtiss L.K. Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst (beige) mutations. Arterioscler Thromb Vasc Biol. 2002; 22: 1341-1346 Crossref PubMed Scopus (50) Google Scholar , 5 Whitman S.C. Rateri D.L. Szilvassy S.J. Yokoyama W. Daugherty A. Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice. Arterioscler Thromb Vasc Biol. 2004; 24: 1049-1054 Crossref PubMed Scopus (125) Google Scholar , 6 Getz G.S. Do natural killer cells participate in a killer vascular disease?. Arterioscler Thromb Vasc Biol. 2002; 22: 1251-1253 Crossref PubMed Scopus (10) Google Scholar , 7 Linton M.F. Major A.S. Fazio S. Proatherogenic role for NK cells revealed. Arterioscler Thromb Vasc Biol. 2004; 24: 992-994 Crossref PubMed Scopus (20) Google Scholar ]. It has been reported that in elderly patients with atherosclerosis, the number of NK cells in the blood are increased while cytotoxicity per NK cell is decreased [ [8] Bruunsgaard H. Pedersen A.N. Schroll M. Skinhoj P. Pedersen B.K. Decreased natural killer cell activity is associated with atherosclerosis in elderly humans. Exp Gerontol. 2001; 37: 127-136 Crossref PubMed Scopus (71) Google Scholar ].