Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
2011; American Association for the Advancement of Science; Volume: 3; Issue: 94 Linguagem: Inglês
10.1126/scitranslmed.3002394
ISSN1946-6242
AutoresDenise A. Chan, Patrick D. Sutphin, Phuong Nguyen, Sandra Turcotte, Edwin W. Lai, Alice Banh, Gloria E. Reynolds, Jen‐Tsan Chi, Jason Wu, David E. Solow-Cordero, Muriel Bonnet, Jack U. Flanagan, Donna M. Bouley, Edward E. Graves, William A. Denny, Michael P. Hay, Amato J. Giaccia,
Tópico(s)Mitochondrial Function and Pathology
ResumoA screen identifies a drug that specifically kills glycolysis-dependent cancer cells by inhibiting glucose uptake.
Referência(s)