Alcohol, sludge, and hypoxic areas of nervous system, liver and heart
1968; Elsevier BV; Volume: 1; Issue: 2 Linguagem: Inglês
10.1016/0026-2862(68)90016-2
ISSN1095-9319
AutoresHerbert Moskow, Raymond C. Pennington, Melvin H. Knisely,
Tópico(s)Neurosurgical Procedures and Complications
ResumoIn 30 adult humans (13 females, 17 males) microscopic observations were made of blood flow and the conditions of the small vessels in the conjunctiva, and at the same time a blood sample was taken for determination of blood ethyl alcohol concentration. Ethanol concentrations ranged from zero to 328 mg/100 ml. With increasing concentrations of alcohol in the blood, the size of aggregated or agglutinated blood cell masses increased, and the forward rates of flow in small vessels decreased correspondingly. With the higher concentrations of blood alcohol and the more severe reduction in forward flow rates, the numbers of vessels in stasis, plugged, occluded, and with no flow increased significantly. Within the extreme upper concentrations of ethanol (225 and 328 mg/100 ml blood) some small vessels were ruptured, producing microscopic hemorrhages into the contiguous bulbar conjunctival tissue. No arrangement of the data, other than in ascending order of blood alcohol concentrations, has given any thus far recognizable trend of meaning. Mechanisms are described whereby reduced rates of blood flow through capillaries and the plugging of capillaries damage brain, liver, and heart.
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