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The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation

2013; Elsevier BV; Volume: 32; Issue: 12 Linguagem: Inglês

10.1016/j.healun.2013.08.011

1557-3117

Gerald J. Berry, Margaret Burke, Claus B. Andersen, Patrick Bruneval, Marny Fedrigo, Michael C. Fishbein, Martin Goddard, Elizabeth H. Hammond, Ornella Leone, Charles C. Marboe, Dylan Miller, Desley Neil, Doris M. Rassl, Mónica P. Revelo, Alexandra Rice, E. René Rodríguez, Susan Stewart, Carmela D. Tan, Gayle L. Winters, Lori J. West, Mandeep R. Mehra, Annalisa Angelini,

Renal Transplantation Outcomes and Treatments

During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. The diagnostic criteria for its morphologic and immunopathologic components are enumerated, illustrated, and described in detail. Numerous challenges and unresolved clinical, immunologic, and pathologic questions remain to which a Working Formulation may facilitate answers.