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Artigo Revisado por pares
BIBTEX RIS

New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities

2009; Elsevier BV; Volume: 18; Issue: 1 Linguagem: Inglês

10.1016/j.bmc.2009.11.017

ISSN

1464-3391

Autores

Maria del Mar Sanchez Duque, Pelayo Camps, Eva Torres, Elena Valverde, Francesc X. Sureda, Marta López-Querol, Antoni Camins, S. Radhika Prathalingam, John M. Kelly, Santiago Vázquez,

Tópico(s)

Pharmacological Receptor Mechanisms and Effects

Resumo

The synthesis of several (1,2,3,5,6,7-hexahydro-1,5:3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity.

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