RECURRENT MISCARRIAGE SYNDROME AND INFERTILITY CAUSED BY BLOOD COAGULATION PROTEIN OR PLATELET DEFECTS
2000; Elsevier BV; Volume: 14; Issue: 5 Linguagem: Inglês
10.1016/s0889-8588(05)70174-x
ISSN1558-1977
Autores Tópico(s)Platelet Disorders and Treatments
ResumoRecurrent miscarriage syndrome (RMS) is a common obstetrical problem affecting more than 500, 000 women per year7; infertility, although less well defined in the population, is also a common clinical problem. Recurrent miscarriage, based on the available literature and the author's experience, is generally caused by certain well-defined defects: about 7% results from chromosomal abnormalities, about 10% is caused by anatomical abnormalities, about 15% seems to result from hormonal abnormalities (progesterone, estrogens, diabetes, or thyroid disease), about 6% cannot be explained, and the remainder, about 55% to 62%, are caused by blood coagulation protein or platelet defects.7 The approximate prevalence of causes of RMS and infertility are summarized in Figure 1.7 In contrast, about 90% of first-time miscarriages are caused by a chromosomal defect and as many as 25% of first-time pregnancies may end in miscarriage.7
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