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Immunoregulatory and Anti-Tumor Effects of Polysaccharopeptide and Astragalus polysaccharides on Tumor-Bearing Mice

2008; Taylor & Francis; Volume: 30; Issue: 4 Linguagem: Inglês

10.1080/08923970802279183

1532-2513

Jin Li, Yixi Bao, Lam Wai-kei, Wenwen Li, Fang Lü, Xuan Zhu, Jing Liu, Hongping Wang,

Mycobacterium research and diagnosis

AbstractThe aim of this study was to determine whether polysaccharopeptide (PSP) and Astragalus polysaccharides (APS) can be combined together as a new complex prescription (PSP + APS) for aiding adriamycin (AMD) chemotherapy. Ehrlich's ascites carcinoma (EAC) was used to establish a solid tumor model in Kunming mice. Immunocytochemical and immunohistochemical analysis were employed to detect the immunoregulatory and anti-tumor effects of EAC bearing mice after 30 days of administration with PSP and APS. PSP and PSP + APS could significantly increase the percentage of CD3+ and CD4+ T-lymphocytes, the ratio of CD4+/CD8+, and the expression of IL-2/IL-2R in spleen and Bax in tumor tissue, but led to a diminution of Bcl-2 and CDK4 in tumor tissue compared with those of control group. In addition, PSP +APS could restore the immunological effects against AMD-induced immunosuppression, such as the subset of leukomonocyte, the expression of IL-2/IL-2R in the spleen, and the thymus index. These findings suggest that the immunomodulatory and anti-cancer effects of this new formula (PSP+APS) were better than those of PSP alone, and also could resist immunosuppression induced by AMD.Keywords: PolysaccharopeptideAstragalus PolysaccharidesComplex PrescriptionImmunoregulatory ActivityAnti-Tumor Effects ACKNOWLEDGMENTSWe thank Professor Yang Qing-yao of Shanghai Normal University who gave us PSP. This study was supported by the funds of Chongqing Science & FIX. Technology Commission and Chongqing Muniprl Education Commission and was carried out at the Key Laboratory of Laboratory Medical Diagnostics (Ministry of Education) in Chongqing Medical University.