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β-Catenin Up-Regulates the Expression of the Urokinase Plasminogen Activator in Human Colorectal Tumors

2004; American Association for Cancer Research; Volume: 64; Issue: 4 Linguagem: Inglês

10.1158/0008-5472.can-3627-2

1538-7445

Elke Hiendlmeyer, Susanne Regus, Stella Wassermann, Falk Hlubek, Angela Haynl, Arno Dimmler, Claudia Koch, Claudia Knoll, Moniek van Beest, Ute Reuning, Thomas Brabletz, Thomas Kirchner, Andreas Jung,

Cancer-related gene regulation

Abstract Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear β-catenin and is therefore a region expressing β-catenin target genes at high levels. Here we show that β-catenin contributes to the transactivation of uPA. Therefore, β-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.