Synthetic Antitumor Vaccines from Tetanus Toxoid Conjugates of MUC1 Glycopeptides with the Thomsen–Friedenreich Antigen and a Fluorine‐Substituted Analogue
2010; Wiley; Volume: 49; Issue: 45 Linguagem: Inglês
10.1002/anie.201003810
ISSN1521-3773
AutoresAnja Hoffmann‐Röder, Anton Kaiser, Sarah Wagner, Nikola Gaidzik, Danuta Kowalczyk, Ulrika Westerlind, Bastian Gerlitzki, Edgar Schmitt, Horst Kunz,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoAngewandte Chemie International EditionVolume 49, Issue 45 p. 8498-8503 Communication Synthetic Antitumor Vaccines from Tetanus Toxoid Conjugates of MUC1 Glycopeptides with the Thomsen–Friedenreich Antigen and a Fluorine-Substituted Analogue† Prof. Dr. Anja Hoffmann-Röder, Prof. Dr. Anja Hoffmann-Röder hokunz@uni-mainz.de Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorAnton Kaiser, Anton Kaiser Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorSarah Wagner, Sarah Wagner Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorNikola Gaidzik, Nikola Gaidzik Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorDanuta Kowalczyk, Danuta Kowalczyk Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorDr. Ulrika Westerlind, Dr. Ulrika Westerlind Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. ISAS—Institute for Analytical Sciences, Otto-Hahn-Strasse 6b, 44227 Dortmund (Germany)Search for more papers by this authorBastian Gerlitzki, Bastian Gerlitzki Johannes Gutenberg-Universität Mainz, Universitätsmedizin Mainz, Institut für Immunologie, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany)Search for more papers by this authorProf. Dr. Edgar Schmitt, Prof. Dr. Edgar Schmitt Johannes Gutenberg-Universität Mainz, Universitätsmedizin Mainz, Institut für Immunologie, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany)Search for more papers by this authorProf. Dr. Horst Kunz, Prof. Dr. Horst Kunz Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this author Prof. Dr. Anja Hoffmann-Röder, Prof. Dr. Anja Hoffmann-Röder hokunz@uni-mainz.de Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorAnton Kaiser, Anton Kaiser Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorSarah Wagner, Sarah Wagner Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorNikola Gaidzik, Nikola Gaidzik Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorDanuta Kowalczyk, Danuta Kowalczyk Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this authorDr. Ulrika Westerlind, Dr. Ulrika Westerlind Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. ISAS—Institute for Analytical Sciences, Otto-Hahn-Strasse 6b, 44227 Dortmund (Germany)Search for more papers by this authorBastian Gerlitzki, Bastian Gerlitzki Johannes Gutenberg-Universität Mainz, Universitätsmedizin Mainz, Institut für Immunologie, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany)Search for more papers by this authorProf. Dr. Edgar Schmitt, Prof. Dr. Edgar Schmitt Johannes Gutenberg-Universität Mainz, Universitätsmedizin Mainz, Institut für Immunologie, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany)Search for more papers by this authorProf. Dr. Horst Kunz, Prof. Dr. Horst Kunz Johannes Gutenberg-Universität Mainz, Institut für Organische Chemie, Duesbergweg 10–14, 55128 Mainz (Germany), Fax: (+49) 6131-392-4786Search for more papers by this author First published: 28 September 2010 https://doi.org/10.1002/anie.201003810Citations: 123 † This work was supported by the Deutsche Forschungsgemeinschaft and the Jürgen Knop-Stiftung. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract A "shot in the arm" for cancer therapy: Coupling of synthetic glycopeptide tandem-repeat sequences of the epithelial mucin MUC1 with the Thomsen–Friedenreich (T) antigen (A) or a difluoro analogue (B) to tetanus toxoid (TTox) affords synthetic vaccines, which induce very strong immune responses in mice overriding the natural tolerance of the immune system. The induced antibodies are selectively directed against the tumor-associated MUC1 structures and strongly bind to breast cancer cells of the MCF-7 cell line. Citing Literature Volume49, Issue45November 2, 2010Pages 8498-8503 RelatedInformation
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