Produção Nacional
Revisado por pares
Biflorin: an o-naphthoquinone of clinical significance
2014; Brazilian Academy of Sciences; Volume: 86; Issue: 4 Linguagem: Inglês
10.1590/0001-3765201420140085
ISSN1678-2690
AutoresGABRIELLE G.N.S. WISINTAINER, Evelyne Rolim Braun Simões, Telma L. G. Lemos, Sidnei Moura, Luciana G. S. Souza, Aluísio Marques da Fonseca, MANOEL ODORICO MORAES, Cláudia Pessoa, Mariana Roesch‐Ely, João Antônio Pêgas Henriques,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoBiflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plant Capraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.
Referência(s)