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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

RNAIII-Inhibiting-Peptide-Loaded Polymethylmethacrylate Prevents In Vivo Staphylococcus aureus Biofilm Formation

2006; American Society for Microbiology; Volume: 51; Issue: 7 Linguagem: Inglês

10.1128/aac.00580-06

ISSN

1098-6596

Autores

Paloma Anguita-Alonso, Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Vittorio Saba, Giorgio Scalise, Milica Ševo, Marina Tuzova, Robin Patel, Naomi Balaban,

Tópico(s)

Bacterial biofilms and quorum sensing

Resumo

ABSTRACT Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.

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