Neurodevelopmental events underlying information acquisition and storage
1992; Taylor & Francis; Volume: 3; Issue: 1 Linguagem: Inglês
10.1088/0954-898x_3_1_010
ISSN1361-6536
AutoresE Doyle, Patrick M. Nolan, R.W. Bell, Ciaran M. Regan,
Tópico(s)Neurogenesis and neuroplasticity mechanisms
ResumoThis brief overview presents evidence to suggest that information storage, in part, may be based on synapse connectivity changes mediated by a replay of neurodevelopmental events. These considerations are based on studies which have monitored change in neural cell adhesion molecule (NCAM) sialylation state during acquisition and consolidation of a passive avoidance response in the adult rat. The synapse-specific isoform of NCAM, NCAM180 is demonstrated to increase sialylation state in the hippocampus between 12-24 h after training and to produce a novel sialylated form of 210 kDa. Interventive studies with specific antibodies showed NCAM to play a specific role at 6-8 h after training, the amnestic effect of which does not become apparent until the process of NCAM sialylation is complete.
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