Tricyclic antidepressants and tryptophan in unipolar depression
1975; Cambridge University Press; Volume: 5; Issue: 3 Linguagem: Inglês
10.1017/s0033291700056646
ISSN1469-8978
AutoresDavid M. Shaw, D. A. MacSweeney, Robyn Hewland, Anthony L. Johnson,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoSynopsis Depressed patients (unipolar) were given one of the following combinations in an attempt to test aspects of the ‘amine hypothesis’ and to find a preferential therapy: (1) clomipramine; (2) clomipramine and tryptophan; (3) desipramine and clomipramine, and (4) desipramine and tryptophan. Treatment (2) should have given optimal potentiation of 5-HT neurones and (3) and (4) should have acted similarly on both serotoninergic and adrenergic pathways. In no group was there any evidence of accelerated recovery, indicating that the process of conversion to normal mood may be more complex than suggested by most versions of the amine hypothesis.
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