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Hepatitis B Virus Infection Is Associated With Impaired Immunological Recovery During Antiretroviral Therapy in the Swiss HIV Cohort Study

2013; Oxford University Press; Volume: 208; Issue: 9 Linguagem: Inglês

10.1093/infdis/jit351

1537-6613

Gilles Wandeler, Thomas Gsponer, Florian Bihl, Enos Bernasconi, Matthias Cavassini, Helen Kovari, Patrick Schmid, Manuel Battegay, Alexandra Calmy, Matthias Egger, Hansjakob Furrer, Andri Rauch, Vincent Aubert, Julia M. I. Barth, Manuel Battegay, Enos Bernasconi, J Böni, Heiner C. Bucher, Claudine Burton‐Jeangros, Alexandra Calmy, Matthias Cavassini, Matthias Egger, Luigia Elzi, Jan Fehr, Jacques Fellay, P Francioli, Hansjakob Furrer, Christoph A. Fux, Meri Gorgievski, H. Günthard, David Haerry, Barbara Hasse, Hans H. Hirsch, B Hirschel, Irène Hösli, Christian R. Kahlert, Laurent Kaiser, Olivia Keiser, Christian Kind, Thomas Klimkait, Helen Kovari, Bruno Ledergerber, G Martinetti, Begoña Martínez de Tejada, Karin J. Metzner, Nora Müller, David Nadal, Giuseppe Pantaleo, Andri Rauch, Stephan Regenass, Martin Rickenbach, C Rudin, Patrick Schmid, D. Schultze, F. Schöni-Affolter, Jörg Schüpbach, René Speck, Patrick Taffé, Philip Tarr, A. Telenti, Alexandra Trkola, P Vernazza, Rachel Weber, Sabine Yerly,

HIV/AIDS Research and Interventions

Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)–infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen–positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.