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Artigo Revisado por pares
BIBTEX RIS

Palladium-Catalyzed Aerobic Oxidative Kinetic Resolution of Alcohols with an Achiral Exogenous Base

2003; American Chemical Society; Volume: 68; Issue: 19 Linguagem: Inglês

10.1021/jo034717r

ISSN

1520-6904

Autores

Sunil K. Mandal, Matthew S. Sigman,

Tópico(s)

Asymmetric Synthesis and Catalysis

Resumo

Substitution of exogenous (-)-sparteine for a more practical achiral base in the aerobic oxidative kinetic resolution of secondary alcohols is described. Carbonate bases are the most effective of those screened and allow for effective kinetic resolution of benzylic, allylic, and aliphatic substrates. The procedure was also successfully extended to the oxidative desymmetrization of meso diols.

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