Focal Laser Ablation for Prostate Cancer Followed by Radical Prostatectomy: Validation of Focal Therapy and Imaging Accuracy
2010; Elsevier BV; Volume: 57; Issue: 6 Linguagem: Inglês
10.1016/j.eururo.2010.03.008
ISSN1873-7560
AutoresUri Lindner, Nathan Lawrentschuk, Robert Weersink, Sean M. Davidson, Orit E. Raz, Eugen Hlasny, Deanna L. Langer, Mark R. Gertner, Theodorus H. van der Kwast, Masoom A. Haider, John Trachtenberg,
Tópico(s)Laser-induced spectroscopy and plasma
ResumoAn increased incidence of low-risk prostate cancer (PCa) has led investigators to develop focal therapy as a management option for PCa. We evaluated the effects of focal laser ablation (FLA) on PCa tissue and the accuracy of magnetic resonance imaging (MRI) in determining ablated lesion volume by comparing the whole-mount histology and MRI in four patients that underwent FLA followed by radical prostatectomy. Ablated areas were characterized by homogeneous coagulation necrosis. The MRI-calculated ablated volume correlated well with histopathology. We found that FLA creates confluent ablation with no evidence of viable cells in treated regions. Postablation MRI is able to determine the ablation accurately.
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