Natural and Synthetic Xanthones as Monoamine Oxidase Inhibitors: Biological Assay and 3D-QSAR
2001; Wiley; Volume: 84; Issue: 3 Linguagem: Inglês
10.1002/1522-2675(20010321)84
ISSN1522-2675
AutoresCarmela Gnerre, Ulrike Thull, Patrick Gaillard, Pierre‐Alain Carrupt, Bernard Testa, Eduarda Fernandes, Francisco A. M. Silva, Manuela Pinto, Madalena Pinto, Jean‐Luc Wolfender, Kurt Hostettmann, Gabriele Cruciani,
Tópico(s)Phytochemicals and Antioxidant Activities
ResumoHelvetica Chimica ActaVolume 84, Issue 3 p. 552-570 Research Article Natural and Synthetic Xanthones as Monoamine Oxidase Inhibitors: Biological Assay and 3D-QSAR Carmela Gnerre, Carmela Gnerre Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorUlrike Thull, Ulrike Thull Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorPatrick Gaillard, Patrick Gaillard Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorPierre-Alain Carrupt, Pierre-Alain Carrupt Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorBernard Testa, Bernard Testa Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorEduarda Fernandes, Eduarda Fernandes Laboratorio de Quimica Organica, Faculdade de Farmacia, rua Anìbal Cunha 164, P-4050 PortoSearch for more papers by this authorFrancisco Silva, Francisco Silva Laboratorio de Quimica Organica, Faculdade de Farmacia, rua Anìbal Cunha 164, P-4050 PortoSearch for more papers by this authorManuela Pinto, Manuela Pinto Laboratorio de Quimica Organica, Faculdade de Farmacia, rua Anìbal Cunha 164, P-4050 PortoSearch for more papers by this authorMadalena M. M. Pinto, Madalena M. M. Pinto Laboratorio de Quimica Organica, Faculdade de Farmacia, rua Anìbal Cunha 164, P-4050 PortoSearch for more papers by this authorJean-Luc Wolfender, Jean-Luc Wolfender Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorKurt Hostettmann, Kurt Hostettmann Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorGabriele Cruciani, Gabriele Cruciani Laboratorio di Chemiometria, Dipartimento di Chimica, Università di Perugia, Via Elce di Sotto 10, I-06123 PerugiaSearch for more papers by this author Carmela Gnerre, Carmela Gnerre Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorUlrike Thull, Ulrike Thull Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorPatrick Gaillard, Patrick Gaillard Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorPierre-Alain Carrupt, Pierre-Alain Carrupt Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorBernard Testa, Bernard Testa Institut de Chimie Thérapeutique, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorEduarda Fernandes, Eduarda Fernandes Laboratorio de Quimica Organica, Faculdade de Farmacia, rua Anìbal Cunha 164, P-4050 PortoSearch for more papers by this authorFrancisco Silva, Francisco Silva Laboratorio de Quimica Organica, Faculdade de Farmacia, rua Anìbal Cunha 164, P-4050 PortoSearch for more papers by this authorManuela Pinto, Manuela Pinto Laboratorio de Quimica Organica, Faculdade de Farmacia, rua Anìbal Cunha 164, P-4050 PortoSearch for more papers by this authorMadalena M. M. Pinto, Madalena M. M. Pinto Laboratorio de Quimica Organica, Faculdade de Farmacia, rua Anìbal Cunha 164, P-4050 PortoSearch for more papers by this authorJean-Luc Wolfender, Jean-Luc Wolfender Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorKurt Hostettmann, Kurt Hostettmann Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 LausanneSearch for more papers by this authorGabriele Cruciani, Gabriele Cruciani Laboratorio di Chemiometria, Dipartimento di Chimica, Università di Perugia, Via Elce di Sotto 10, I-06123 PerugiaSearch for more papers by this author First published: 29 March 2001 https://doi.org/10.1002/1522-2675(20010321)84:3 3.0.CO;2-XCitations: 57AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Fifty-nine xanthones (=9H-xanthen-9-ones) of natural or synthetic origin were investigated for their inhibitory activity toward monoamine-oxidase A (MAO-A) and MAO-B. The compounds demonstrated reversible, time-independent activities, with selectivity toward MAO-A. The most active inhibitor had an IC50 of 40 nM. Electron absorption spectroscopy revealed the formation of a 1 : 1 charge-transfer complex between lumiflavine and xanthones. 3D-QSAR Studies according to the CoMFA/GOLPE procedure provided information on the relationship between steric and electrostatic fields and MAO-A inhibition. The ALMOND procedure yielded additional topographical information on structural factors favoring activity. Citing Literature Volume84, Issue3March 21, 2001Pages 552-570 RelatedInformation
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