Overexpression of p8 Is Inversely Correlated with Apoptosis in Pancreatic Cancer
2001; American Association for Cancer Research; Volume: 7; Issue: 5 Linguagem: Inglês
ISSN
1557-3265
AutoresShi-Bing Su, Yoshiharu Motoo, Juan Iovanna, Patrice Berthézène, Min-Jue Xie, Hisatsugu Mouri, Koushiro Ohtsubo, Fujitsugu Matsubara, Norio Sawabu,
Tópico(s)Cancer Research and Treatments
ResumoA recently identified gene, p8, has cell growth-promoting activity and is strongly induced in acute pancreatitis. In this study, we detected p8 and single-stranded DNA (ssDNA) for apoptosis by immunohistochemistry in human pancreatic cancer. The p8 was overexpressed (>30% per 1000 cancer cells) in 26 of 44 (59%) pancreatic cancers, and apoptosis (ssDNA-positive cells >10% per 1000 cancer cells) was recognized in 18 of 44 (41%) pancreatic cancers. There was a significant inverse correlation between the p8 overexpression and apoptosis (P < 0.05). Moreover, the expression pattern of high p8 and low ssDNA was seen significantly more often in lower age (<65 years), in moderately or poorly differentiated cancers, and in node-positive cases (P < 0.05). The p8 expression and apoptosis were not significantly correlated with survival. These results suggest that p8 overexpression is involved in antiapoptotic activity and the biological characteristics of pancreatic cancer.
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