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Chemical constituents from Bakeridesia pickelii Monteiro (Malvaceae) and the relaxant activity of kaempferol-3-O-beta-D-(6"-E-p -coumaroyl) glucopyranoside on guinea-pig ileum

2007; Brazilian Chemical Society; Volume: 30; Issue: 4 Linguagem: Inglês

10.1590/s0100-40422007000400026

1678-7064

Danielly Albuquerque da Costa, Davi Antas e Silva, Aline Coutinho Cavalcanti, Marcos Antônio Alves de Medeiros, Julianeli Tolentino de Lima, José Marcílio Sobral Cavalcante, Bagnólia Araújo da Silva, Maria de Fátima Agra, María de Fátima Vanderlei de Souza,

Traditional and Medicinal Uses of Annonaceae

The phytochemical investigation of Bakeridesia pickelii Monteiro led to the isolation of seven compounds: β-sitosterol, a mixture of sitosteryl-3-O-β-D-glucopyranoside and stigmasteryl-3-O-β-D-glucopyranoside, vanillic acid, p-coumaric acid, quercetin 3-O-β-Dglucopyranoside (isoquercitrin) and kaempferol-3-O-β-D-(6"-E-p-coumaroyl) glucopyranoside (tiliroside), which was isolated as the major component.Their structures were elucidated on the basis of spectroscopic data such as IR, 1 H and 13 C NMR, including twodimensional techniques.Tiliroside relaxed the guinea-pig ileum pre-contracted with KCl 40 mM (EC 50 = 9.5 ± 1.0 x 10 -5 M), acetylcholine 10 -6 M (EC 50 = 2.3 ± 0.9 x 10 -5 M) or histamine 10 -6 M (EC 50 = 4.1 ± 1.0 x 10 -5 M) in a concentration-dependent manner.