The nature of fibrous dysplasia
2009; BioMed Central; Volume: 5; Issue: 1 Linguagem: Inglês
10.1186/1746-160x-5-22
ISSN1746-160X
AutoresL. Feller, Neil Wood, R A G Khammissa, J Lemmer, Erich J. Raubenheimer,
Tópico(s)Oral and Maxillofacial Pathology
ResumoFibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption.
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