Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Structural Basis for Depletion of Heat Shock Protein 90 Client Proteins by Deguelin

2007; Oxford University Press; Volume: 99; Issue: 12 Linguagem: Inglês

10.1093/jnci/djm007

ISSN

1460-2105

Autores

Seung Hyun Oh, Jong Kyu Woo, Yasemin D. Yazici, Jeffrey N. Myers, Woo-Young Kim, Quanyi Jin, Soon‐Sun Hong, Hae‐Jeong Park, Young‐Ger Suh, K.-W. Kim, Waun Ki Hong, Ho‐Young Lee,

Tópico(s)

Endoplasmic Reticulum Stress and Disease

Resumo

BackgroundThe molecular chaperone heat shock protein 90 (Hsp90) participates in preserving the expression and activity of various oncoproteins, including hypoxia-inducible factor 1α (HIF-1α) and Akt. Deguelin is a rotenoid with antitumor activities. We investigated whether the antitumor activities of deguelin involve the functional inhibition of Hsp90.

Referência(s)