Cardiac Magnetic Resonance Imaging and Eosinophilic Endomyocardial Fibrosis
2008; Lippincott Williams & Wilkins; Volume: 118; Issue: 23 Linguagem: Inglês
10.1161/circulationaha.108.781492
ISSN1524-4539
AutoresOlivier Genée, Jérôme Fichet, D. Alison,
Tópico(s)Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
ResumoHomeCirculationVol. 118, No. 23Cardiac Magnetic Resonance Imaging and Eosinophilic Endomyocardial Fibrosis Free AccessReview ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissionsDownload Articles + Supplements ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toSupplementary MaterialsFree AccessReview ArticlePDF/EPUBCardiac Magnetic Resonance Imaging and Eosinophilic Endomyocardial Fibrosis Olivier Genée, MD, Jérôme Fichet, MD and Daniel Alison, MD Olivier GenéeOlivier Genée From Unité de Soins Intensifs Cardiologiques, Pôle Cœur-Thorax-Vaisseaux-Hémostase (O.G.), Service de Réanimation Médicale Polyvalente (J.F.), and Service de Radiologie Adulte, Pôle Imagerie Médicale (D.A.), Centre Hospitalier Régional Universitaire de Tours, Université François Rabelais, Tours, France. , Jérôme FichetJérôme Fichet From Unité de Soins Intensifs Cardiologiques, Pôle Cœur-Thorax-Vaisseaux-Hémostase (O.G.), Service de Réanimation Médicale Polyvalente (J.F.), and Service de Radiologie Adulte, Pôle Imagerie Médicale (D.A.), Centre Hospitalier Régional Universitaire de Tours, Université François Rabelais, Tours, France. and Daniel AlisonDaniel Alison From Unité de Soins Intensifs Cardiologiques, Pôle Cœur-Thorax-Vaisseaux-Hémostase (O.G.), Service de Réanimation Médicale Polyvalente (J.F.), and Service de Radiologie Adulte, Pôle Imagerie Médicale (D.A.), Centre Hospitalier Régional Universitaire de Tours, Université François Rabelais, Tours, France. Originally published2 Dec 2008https://doi.org/10.1161/CIRCULATIONAHA.108.781492Circulation. 2008;118:e710–e711We report the case of a 41-year-old man who presented with lymphoma 2 years ago and was treated by chemotherapy. Biological findings revealed important eosinophilia, although explorations did not show any lymphoma recidivism or evidence of active infection. One month later, the patient presented with fever and clinical signs of heart failure as the onset of a central catheter infection occurred with methicillin-resistant Staphylococcus aureus bacteremia. Chest radiography revealed an enlarged cardiac shadow with a congestive vascular pattern (Figure, A). The ECG showed sinus tachycardia with incomplete left bundle-branch block (Figure, B). The echocardiogram revealed severe mitral and aortic regurgitation with apical filling of the left ventricle by a mobile structure (Figure, C). An initial diagnosis of severe mitral and aortic endocarditis was made, and valvular surgery replacement was recommended. Download figureDownload PowerPointFigure. A, Chest radiograph. Note the enlarged cardiac shadow with congestive vascular pattern. B, ECG on admission. Note the sinus tachycardia and the incomplete left bundle-branch block with low QRS voltage in the frontal leads. C, Left, Echocardiogram apical 4-chamber view. Note the apical filling of the left ventricle. Left ventricle ejection fraction was moderately decreased at 54%. Right, Echocardiogram apical 4-chamber view centered on the mitral valve, with color Doppler. Note the severe mitral regurgitation, with regurgitation output of 156 mL/s by PISA (proximal isovelocity surface area) evaluation. D, Steady state free precession MRI transverse view through both ventricles 2 minutes after 0.2-mmol/kg Gd-DTPA infusion. Note the apical filling of the left ventricle by thrombus (★) exhibiting lower signal than adjacent myocardium. E, Delayed enhanced sequence in the same axis 10 minutes after Gd-DTPA infusion. Subendocardium exhibited high signal (arrows) close to the ventricular thrombus (★).A cardiac MRI performed before the planned valvular surgery revealed normal wall thickening in pre- and post-gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) infusion dynamic sequences (Figure, D; Data Supplement Movie), with a large thrombus (*) filling the apex. A delayed-enhancement sequence 10 minutes after infusion of 0.2 mmol Gd-DTPA per kilogram of body weight emphasized a hypersignal in the subendocardium (Figure, E, arrows). Gd-DTPA infusion allowed both the characterization of thrombus by evidence of no early or late enhancement and of myocardial fibrosis by delayed enhancement. Myocardial scarring or necrosis increases gadolinium concentration, which explains the delayed hyperenhancement.1 The exclusive involvement of endomyocardium with respect to the myocardial wall, demonstrated by endomyocardial delayed enhancement and normal myocardial thickening, confirmed this hypothesis. The diagnosis of endomyocardial fibrosis associated with this bivalvular endocarditis was made on the basis of this typical MRI finding.2,3 Despite valvular replacement and aggressive intensive care, the patient died of septic shock due to recurrence of endocarditis 9 days later.Hypereosinophilic syndrome includes a large heterogeneity of systemic manifestations associated with a persistent hypereosinophilia for more than 6 months. This syndrome is considered idiopathic in the absence of neoplasm, allergic or infective disease, or specific organ involvement.4 In both idiopathic and secondary hypereosinophilic syndromes, cardiac manifestation induces a high morbidity rate with a dire prognosis.5 Cardiac involvement is characterized by a restrictive pattern that is sometimes associated with severe atrioventricular valvular dysfunction. Restrictive cardiomyopathy is considered to be due to toxic damage produced by activated eosinophils, which provoke endomyocardium fibrosis with obliteration of the right and left ventricles.4,6 The cause of valvular regurgitation is less well established but appears to be consistent with the same physiopathology. Cardiac MRI may represent an important tool for early diagnosis and management of this rare but severe disease.The online-only Data Supplement is available with this article at http://circ.ahajournals.org/cgi/content/full/118/23/e710/DC1.DisclosuresNone.FootnotesCorrespondence to Dr Genée Olivier, Unité de Soins Intensifs Cardiologiques, Pôle Cœur-Thorax-Vaisseaux-Hémostase, Hôpital Trousseau, CHRU de Tours, 37044 Tours Cedex 9, France. E-mail [email protected]References1 Mahrholdt H, Wagner A, Judd RM, Sechtem U, Kim RJ. Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies. Eur Heart J. 2005; 26: 1461–1474.CrossrefMedlineGoogle Scholar2 Salanitri GC. Endomyocardial fibrosis and intracardiac thrombus occurring in idiopathic hypereosinophilic syndrome. Am J Roentgenol. 2005; 184: 1432–1433.CrossrefMedlineGoogle Scholar3 Syed IS, Martinez MW, Feng DL, Glockner JF. Cardiac magnetic resonance imaging of eosinophilic endomyocardial disease. Int J Cardiol. 2008; 126: e50–e52.CrossrefMedlineGoogle Scholar4 Fauci AS, Harley JB, Roberts WC, Ferrans VJ, Gralnick HR, Bjornson BH. NIH conference: the idiopathic hypereosinophilic syndrome: clinical, pathophysiologic, and therapeutic considerations. Ann Intern Med. 1982; 97: 78–92.CrossrefMedlineGoogle Scholar5 Ommen SR, Seward JB, Tajik AJ. Clinical and echocardiographic features of hypereosinophilic syndromes. Am J Cardiol. 2000; 86: 110–113.CrossrefMedlineGoogle Scholar6 Kushwaha SS, Fallon JT, Fuster V. Restrictive cardiomyopathy. N Engl J Med. 1997; 336: 267–276.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Scatularo C, Posada Martínez E, Saldarriaga C, Ballesteros O, Baranchuk A, Sosa Liprandi A, Wyss F and Sosa Liprandi M (2021) Endomyocardiofibrosis: A Systematic Review, Current Problems in Cardiology, 10.1016/j.cpcardiol.2020.100784, 46:4, (100784), Online publication date: 1-Apr-2021. Beaton A and Mocumbi A (2017) Diagnosis and Management of Endomyocardial Fibrosis, Cardiology Clinics, 10.1016/j.ccl.2016.08.005, 35:1, (87-98), Online publication date: 1-Feb-2017. Grimaldi A, Mocumbi A, Freers J, Lachaud M, Mirabel M, Ferreira B, Narayanan K, Celermajer D, Sidi D, Jouven X and Marijon E (2016) Tropical Endomyocardial Fibrosis, Circulation, 10.1161/CIRCULATIONAHA.115.021178, 133:24, (2503-2515), Online publication date: 14-Jun-2016. Gupta A, Singh Gulati G, Seth S and Sharma S (2012) Cardiac MRI in restrictive cardiomyopathy, Clinical Radiology, 10.1016/j.crad.2011.05.020, 67:2, (95-105), Online publication date: 1-Feb-2012. Karamitsos T, Francis J and Neubauer S (2011) The Current and Emerging Role of Cardiovascular Magnetic Resonance in the Diagnosis of Nonischemic Cardiomyopathies, Progress in Cardiovascular Diseases, 10.1016/j.pcad.2011.08.007, 54:3, (253-265), Online publication date: 1-Nov-2011. Karamitsos T, Francis J, Myerson S, Selvanayagam J and Neubauer S (2009) The Role of Cardiovascular Magnetic Resonance Imaging in Heart Failure, Journal of the American College of Cardiology, 10.1016/j.jacc.2009.04.094, 54:15, (1407-1424), Online publication date: 1-Oct-2009. December 2, 2008Vol 118, Issue 23 Advertisement Article InformationMetrics https://doi.org/10.1161/CIRCULATIONAHA.108.781492PMID: 19047586 Originally publishedDecember 2, 2008 PDF download Advertisement SubjectsCardiomyopathyComputerized Tomography (CT)Heart Failure
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