Effect of Intra-arterial Insulin on Tissue Cholesterol and Fatty Acids in Alloxan-Diabetic Dogs
1961; Lippincott Williams & Wilkins; Volume: 9; Issue: 1 Linguagem: Inglês
10.1161/01.res.9.1.39
ISSN1524-4571
AutoresAnatolio B. Cruz, Donald S. Amatuzio, Francisco Grande, Lyle J. Hay,
Tópico(s)Adipose Tissue and Metabolism
ResumoInsulin and saline were injected into the right and left femoral arteries respectively of 19 alloxan-diabetes-mellitus dogs for 1 to 28 weeks. A significant increase of artery tissue cholesterol and total fatty acids was found on comparing the insulin-administered right leg with the saline-administered left leg. Similarly, a significant increase of total fatty acids in muscle was found on comparing the right with the left leg of the alloxan-diabetes mellitus dogs. No significant differences were observed in the normal animals when the insulin-injected side was compared with the noninjected.
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