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Efficient Enantioselective Reduction of Ketones with Daucus carota Root

2002; American Chemical Society; Volume: 67; Issue: 11 Linguagem: Inglês

10.1021/jo010399p

1520-6904

Jagjit S. Yadav, Samik Nanda, P. Thirupathi Reddy, A. Bhaskar Rao,

Carbohydrate Chemistry and Synthesis

A novel and efficient reduction of various prochiral ketones such as acetopehones, α-azido aryl ketones, β-ketoesters, and aliphatic acyclic and cyclic ketones to the corresponding optically acive secondary alcohols with moderate to excellent chemical yield was achieved by using Daucus carota, root plant cells under extremely mild and environmentally benign conditions in aqueous medium, has been described. Many of these optically active alcohols are the potential chiral building blocks for the synthesis of pharmaceutically important molecules and asymmetric chiral ligands. Hence, this biocatalytic approach is found to be the most suitable for the preparation of a wide range of chiral alcohols and gave inspiration for the development of a new biotechnological process.