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The insulin‐like growth factor system and diabetes—an overview

2006; Wiley; Volume: 23; Issue: s1 Linguagem: Inglês

10.1111/j.1464-5491.2006.01833f.x

1464-5491

Adrian Heald, R. Stephens, Martin Gibson,

Lipid metabolism and disorders

Diabetic MedicineVolume 23, Issue s1 p. 19-24 The insulin-like growth factor system and diabetes—an overview A. Heald, A. Heald Bishop Auckland Hospital, Co. Durham and Hope Hospital, Salford, UKSearch for more papers by this authorR. Stephens, R. Stephens Bishop Auckland Hospital, Co. Durham and Hope Hospital, Salford, UKSearch for more papers by this authorJ. M. Gibson, J. M. Gibson Bishop Auckland Hospital, Co. Durham and Hope Hospital, Salford, UKSearch for more papers by this author A. Heald, A. Heald Bishop Auckland Hospital, Co. Durham and Hope Hospital, Salford, UKSearch for more papers by this authorR. Stephens, R. Stephens Bishop Auckland Hospital, Co. Durham and Hope Hospital, Salford, UKSearch for more papers by this authorJ. M. Gibson, J. M. Gibson Bishop Auckland Hospital, Co. Durham and Hope Hospital, Salford, UKSearch for more papers by this author First published: 16 February 2006 https://doi.org/10.1111/j.1464-5491.2006.01833f.xCitations: 15Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Further reading 1 Holly J. Physiology of the IGF-system. In Biology of IGF-I: Its Interaction with Insulin in Health and Malignant States. Chichester: John Wiley and Sons 2004; 19–35. 2 Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocrin Rev 1995; 16: 3–34. 3 Juul A. Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res 2003; 13: 113–170. 4 Sandhu MS, Heald AH, Gibson JM, Cruickshank JK, Dunger DB, Wareham NJ. Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study. Lancet 2002; 359 (9319): 1740–1745. 5 Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors. Endocr Rev 1994; 15: 80–101. 6 Ukkola O, Sun G, Bouchard C. Insulin-like growth factor 2 (IGF2) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes. Diabetologia 2001; 44: 2231–2236. 7 Vaessen N, Heutink P, Janssen JA, Witteman JC, Testers L, Hofman A et al. A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction. Diabetes 2001; 50: 637–642. References 1 Holly J. Physiology of the IGF system. Novartis Found Symp 2004; 262: 19–26. 2 Lee PD, Giudice LC, Con Over CA, Powell DR. Insulin-like growth factor binding protein-1: recent findings and new directions. Proc Soc Exp Biol Med 1997; 216: 319–357. 3 Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Et Al. Liver-specific IGF-1 gene deletion leads to muscle insulin insensitivity. Diabetes 2001; 50: 1110–1118. 4 Sesti G, Sciacqua A, Cardellini M, Marini MA, Maio R, Vatrano M, Et Al. Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance. Diabetes Care 2005; 28: 120–125. 5 Sandhu MS, Heald AH, Gibson JM, Cruickshank JK, Dunger DB, Wareham NJ. Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study. Lancet 2002; 359: 1740–1745. 6 Sandhu MS, Gibson JM, Heald AH, Dunger DB, Wareham NJ. 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IGF-I/IGF-binding protein-3 combination improves insulin resistance by GH-dependent and independent mechanisms. J Clin Endocrinol Metab 2002; 87: 4356–4360. 22 Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors. Endocr Rev 1994; 15: 80–101. 23 Heald AH, Cade JE, Cruickshank JK, Anderson S, White A, Gibson JM, Et Al. The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study. Public Health Nutr 2003; 6: 175–180. 24 Heald AH, Anderson SG, Vyas A, Et Al. Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India. Diabetologia 2005; 25 Frayling TM, Hattersley AT, McCarthy A, Holly J, Mitchell SM, Gloyn AL, Et Al. A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in UK populations. Diabetes 2002; 51: 2313–2316. 26 Rietveld I, Janssen JA, Hofman A, Pols HA, van Duijn CM, Lamberts SW. A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. Eur J Endocrinol 2003; 148: 171–175. 27 Johnston LB, Dahlgren J, Leger J, Gelander L, Savage MO, Czernichow P, Et Al. Association between insulin-like growth factor I (IGF-I) polymorphisms, circulating IGF-I, and pre- and postnatal growth in two European small for gestational age populations. J Clin Endocrinol Metab 2003; 88: 4805–4810. 28 Vaessen N, Janssen JA, Heutink P, Hofman A, Lamberts SW, Oostra BA, Et Al. Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight. Lancet 2002; 359: 1036–1037. 29 Gu D, O'Dell SD, Chen XH, Miller GJ, Day IN. Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11. Hum Genet 2002; 110: 173–181. 30 O'Dell SD, Bujac SR, Miller GJ, Day IN. Associations of IGF2 ApaI RFLP and INS VNTR class I allele size with obesity. Eur J Hum Genet 1999; 7: 821–827. 31 Giannoukakis N, Deal C, Paquette J, Kukuvitis A, Polychronakos C. Polymorphic functional imprinting of the human IGF2 gene among individuals, in blood cells, is associated with H19 expression. Biochem Biophys Res Commun 1996; 220: 1014–1019. 32 Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh CL, Feinberg AP. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res 2002; 62: 6442–6446. 33 Rodriguez S, Gaunt TR, O'Dell SD, Chen XH, Gu D, Hawe E, Et Al. Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits. Hum Mol Genet 2004; 13: 715–725. 34 Gaunt TR, Cooper JA, Miller GJ, Day IN, O'Dell SD. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Hum Mol Genet 2001; 10: 1491–1501. 35 Ukkola O, Sun G, Bouchard C. Insulin-like growth factor 2 (IGF2) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes. Diabetologia 2001; 44: 2231–2236. 36 Stephens RH, McElduff P, Heald AH, Ukkola O, Sun G, Bouchard C. Polymorphisms in insulin-like growth factor-binding protein 1 are associated with impaired renal function in Type-2 diabetes mellitus. Diabetes 2005; (in press). 37 Deal C, Ma J, Wilkin F, Paquette J, Rozen F, Ge B, Et Al. Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators. J Clin Endocrinol Metab 2001; 86: 1274–1280. Citing Literature Volume23, Issues1March 2006Pages 19-24 ReferencesRelatedInformation