Lovastatin possesses a fungistatic effect against Candida albicans , but does not trigger apoptosis in this opportunistic human pathogen
2006; Oxford University Press; Volume: 6; Issue: 8 Linguagem: Inglês
10.1111/j.1567-1364.2006.00097.x
ISSN1567-1364
AutoresÃgnes Gyetvai, Tamás Emri, Krisztina Takács, T. Dergez, Andrea Fekete, Miklà s Pesti, István Pà csi, Béla Lenkey,
Tópico(s)Antifungal resistance and susceptibility
ResumoLovastatin inhibited the growth of Candida albicans in a fungistatic way. Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might arise from its negative influence on membrane fluidity. Because yeast-->pseudomycelium and hyphae morphogenetic transitions took place under exposure to lovastatin morphogenetic switch and apoptotic cell death must be regulated independently in C. albicans.
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