Prediction of invasive pulmonary aspergillosis from colonisation of lower respiratory tract before marrow transplantation
1998; Elsevier BV; Volume: 352; Issue: 9138 Linguagem: Inglês
10.1016/s0140-6736(05)61265-2
ISSN1474-547X
AutoresHermann Einsele, K. Quabeck, K-D Müller, Holger Hebart, Ines Rothenhöfer, Jürgen Löffler, UW Schaefer,
Tópico(s)Neutropenia and Cancer Infections
ResumoInvasive pulmonary aspergillosis (IPA) is an increasingly recognised disorder among patients receiving immunosuppressive therapy. Nosocomial inhalation of airborne spores was believed to account for all cases of IPA. Some reports suggest that the proliferation of Aspergillus species spores colonising the lower respiratory tract is a different pathomechanism. 1 Robertson MJ Larson RA Recurrent fungal pneumonias in patients with acute non-lymphocytic leukemia undergoing multiple courses of intensive chemotherapy. Am J Med. 1988; 84: 233-239 Summary Full Text PDF PubMed Scopus (112) Google Scholar , 2 Nawada R Amitani R Tanaka E et al. Murine model of invasive pulmonary Aspergillosis following an earlier stage, noninvasive Aspergillus infection. J Clin Microbiol. 1996; 34: 1433-1439 PubMed Google Scholar This hypothesis of reactivation of the pathogen is supported by the observation that patients with a history of IPA have high risk of recurrence during subsequent immunosuppression, even with a sterile air supply. 1 Robertson MJ Larson RA Recurrent fungal pneumonias in patients with acute non-lymphocytic leukemia undergoing multiple courses of intensive chemotherapy. Am J Med. 1988; 84: 233-239 Summary Full Text PDF PubMed Scopus (112) Google Scholar
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