Fmoc/Trt‐amino acids: comparison to Fmoc/tBu‐amino acids in peptide synthesis
1998; Wiley; Volume: 51; Issue: 3 Linguagem: Inglês
10.1111/j.1399-3011.1998.tb01216.x
ISSN1399-3011
AutoresKleomenis Barlos, Dimitrios Gatos, Sofia Koutsogianni,
Tópico(s)Peptidase Inhibition and Analysis
ResumoModel peptides containing the nucleophilic amino acids Trp and Met have been synthesized with the application of Fmoc/Trt‐ and Fmoc/tBu‐amino acids, for comparison. The deprotection of the peptides synthesized using Fmoc/Trt‐amino acids in all cases leads to crude peptides of higher purity than that of the same peptides synthesized using Fmoc/tBu‐amino acids. © Munksgaard 1998.
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