Artigo Revisado por pares

Association between the oxidative polymorphism and early onset of Parkinson's disease*

1995; Wiley; Volume: 57; Issue: 3 Linguagem: Inglês

10.1016/0009-9236(95)90154-x

ISSN

1532-6535

Autores

José A. G. Agúndez, Félix Javier Jiménez‐Jiménez, Antonio Luengo, M.L. Bernal, José Antonio Molina, Lucía Llorente Ayuso, Antonio Vázquez, Jaime Parra, J. Duarte, F. Coria, José M. Ladero, José C. Alvarez, Julio Benítez,

Tópico(s)

Histone Deacetylase Inhibitors Research

Resumo

Clinical Pharmacology & TherapeuticsVolume 57, Issue 3 p. 291-298 Pharmacokinetics and Drug Disposition Association between the oxidative polymorphism and early onset of Parkinson's disease José A. G. Agúndez MD, PhD, José A. G. Agúndez MD, PhD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorFélix J. Jiménez-Jiménez MD, Félix J. Jiménez-Jiménez MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorAntonio Luengo MD, Antonio Luengo MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorMaría L. Bernal MD, PhD, María L. Bernal MD, PhD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJosé A. Molina MD, José A. Molina MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorLucía Ayuso MD, Lucía Ayuso MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorAntonio Vázquez MD, Antonio Vázquez MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJaime Parra MD, Jaime Parra MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJacinto Duarte MD, Jacinto Duarte MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorFrancisco Coria MD, Francisco Coria MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJosé M. Ladero MD, PhD, José M. Ladero MD, PhD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJosé C. Alvarez MD, José C. Alvarez MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJulio Benítez MD, PhD, Corresponding Author Julio Benítez MD, PhD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainJulio Benítez, MD, PhD, Departamento de Farmacología, Facultad de Medicina, Universidad de Extremadura, Avda. de Elvas s/n, 06071, Badajoz, SpainSearch for more papers by this author José A. G. Agúndez MD, PhD, José A. G. Agúndez MD, PhD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorFélix J. Jiménez-Jiménez MD, Félix J. Jiménez-Jiménez MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorAntonio Luengo MD, Antonio Luengo MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorMaría L. Bernal MD, PhD, María L. Bernal MD, PhD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJosé A. Molina MD, José A. Molina MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorLucía Ayuso MD, Lucía Ayuso MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorAntonio Vázquez MD, Antonio Vázquez MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJaime Parra MD, Jaime Parra MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJacinto Duarte MD, Jacinto Duarte MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorFrancisco Coria MD, Francisco Coria MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJosé M. Ladero MD, PhD, José M. Ladero MD, PhD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJosé C. Alvarez MD, José C. Alvarez MD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainSearch for more papers by this authorJulio Benítez MD, PhD, Corresponding Author Julio Benítez MD, PhD Department of Pharmacology, Medical School, University of Extremadura, Badajoz Section of Neurology, University Hospital Principe de Asturias, Alcalá de Henares, the Service of Neurology, Hospital de la Princesa, the Service of Neurology, Hospital Doce de Octubre, the Services of Neurology and Gastroenterology, University Hospital San Carlos, and the Service of Neurology, Hospital Ramón y Cajal, Madrid Service of Neurology, General Hospital, Segovia, SpainJulio Benítez, MD, PhD, Departamento de Farmacología, Facultad de Medicina, Universidad de Extremadura, Avda. de Elvas s/n, 06071, Badajoz, SpainSearch for more papers by this author First published: March 1995 https://doi.org/10.1016/0009-9236(95)90154-XCitations: 13 Supported in part by grants CICYT-SAF92-0333 from Comision Interministerial de Ciencia y Tecnología, Madrid, Spain, and FISss 93/0632 from Fondo de Investigaciones Sanitarias de la Seguridad Social, Madrid, Spain. This work has been done within a European collaborative group of the Center for Cooperation in the field of Scientific and Technical Research (COST) of the European Communities (EC), project B1, phase II. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The frequency of five cytochrome P450IID6 allelic variants was studied in deoxyribonucleic acid from 123 patients with Parkinson's disease and 150 healthy volunteers. This was chieved by the use of mutation-specific polymerase chain reaction and restriction fragment length polymorphism. The analyses of the CYP2D6 genotype revealed no evidence for a higher prevalence of poor metabolizers among patients with Parkinson's disease. However, increased frequency of patients with Parkinson's disease with the genotype CYP2D6wt/CYP2D6B was observed. This is attributable exclusively to subjects with early onset of the disease (28 to 49 years), with a relative risk ratio of 4.16 (95% confidence limits, 2.0 to 8.3; p < 0.0005). The subjects who had late-onset Parkinson's disease (≥50 years) had genotypes and CYP2D6 allele frequencies similar to the healthy subjects. This indicates that the oxidative polymorphism is related to early-onset but not to late-onset Parkinson's disease. A different influence of CYP2D6 genotype on the risk of development of Parkinson's disease is observed in Spaniards, compared with previous findings in British subjects. These results suggest the combined effect of environmental toxins and CYP2D6 in the cause of Parkinson's disease. Clinical Pharmacology & Therapeutics (1995) 57, 291–298; doi: Citing Literature Volume57, Issue3March 1995Pages 291-298 RelatedInformation

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