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Glibenclamide, a Blocker of K + ATP Channels, Shows Antileishmanial Activity in Experimental Murine Cutaneous Leishmaniasis

2006; American Society for Microbiology; Volume: 50; Issue: 12 Linguagem: Inglês

10.1128/aac.00617-06

1098-6596

Xenón Serrano-Martín, Gilberto Payares, Alexis Mendoza-León,

Synthesis and Biological Evaluation

ABSTRACT Glibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania ( Leishmania ) mexicana , the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in animals infected with a glibenclamide-resistant line, but combined therapy reduced lesion progression even in the glibenclamide-resistant strain.