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Phagocytosis of Antigens by Langerhans Cells

1993; Springer Nature; Linguagem: Inglês

10.1007/978-1-4615-2930-9_33

2214-8019

Caetano Reis e Sousa, Jonathan M. Austyn,

T-cell and B-cell Immunology

Unlike B cells, T cells do not recognise antigen in its native form. Instead, T cell receptors have evolved to recognise peptide fragments in association with MHC molecules on cell surfaces. MHC molecules of the class I type normally associate with peptides derived from endogenous antigens, such as cytosolic proteins, and are ideally placed for presenting viral antigens in infected cells1. MHC class II molecules (Ia) are primarily involved in presenting peptides derived from exogenous antigens and are restricted to a more limited number of cell types such as the dendritic cell2.