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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Inactivation of rifampin by Nocardia brasiliensis

1993; American Society for Microbiology; Volume: 37; Issue: 6 Linguagem: Inglês

10.1128/aac.37.6.1313

ISSN

1098-6596

Autores

Kazunaga Yazawa, Yoshinori Mikami, Akio Maeda, Mitsutaro Akao, Naoko Morisaki, Shintaro Iwasaki,

Tópico(s)

Infectious Diseases and Mycology

Resumo

Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species.

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