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Mapping Human Genetic Diversity in Asia

2009; American Association for the Advancement of Science; Volume: 326; Issue: 5959 Linguagem: Inglês

10.1126/science.1177074

1095-9203

Mahmood Ameen Abdulla, Ikhlak Ahmed, Anunchai Assawamakin, Jong Bhak, Samir K. Brahmachari, Gayvelline C. Calacal, Amit Chaurasia, Chien-Hsiun Chen, Jieming Chen, Yuan-Tsong Chen, Jiayou Chu, Eva Maria C. Cutiongco–de la Paz, Maria Corazon A. De Ungria, Frederick C. Delfin, Juli Edo, Suthat Fuchareon, Ho Ghang, Takashi Gojobori, Junsong Han, Sheng-Feng Ho, Boon‐Peng Hoh, Wei Huang, Hidetoshi Inoko, Pankaj Jha, Timothy A. Jinam, Jin Li, Jongsun Jung, Daoroong Kangwanpong, Jatupol Kampuansai, Giulia C. Kennedy, Preeti Khurana, Hyung Lae Kim, Kwang-Joong Kim, Sangsoo Kim, Woo-Yeon Kim, Kuchan Kimm, Ryosuke Kimura, Tomohiro Koike, Supasak Kulawonganunchai, Vikrant Kumar, Poh San Lai, Jong‐Young Lee, Sunghoon Lee, Edison T. Liu, Partha P. Majumder, Kiran Kumar Mandapati, Sangkot Marzuki, Wayne Mitchell, Mitali Mukerji, Kenji Naritomi, Chumpol Ngamphiw, Norio Niikawa, Nao Nishida, Bermseok Oh, Sang Ho Oh, Jun Ohashi, Akira Oka, Rick Twee‐Hee Ong, Carmencita D. Padilla, Prasit Palittapongarnpim, Henry B. Perdigon, Maude E. Phipps, Eileen Png, Yoshiyuki Sakaki, Jazelyn M. Salvador, Yuliana Sandraling, Vinod Scaria, Mark Seielstad, Mohd Ros Sidek, Amit Kumar Sinha, Metawee Srikummool, Herawati Sudoyo, Sumio Sugano, Helena Suryadi, Yoshiyuki Suzuki, Kristina Tabbada, Adrian Tan, Katsushi Tokunaga, Sissades Tongsima, Lilian P. Villamor, Eric Wang, Ying Wang, Haifeng Wang, Jer-Yuarn Wu, Huasheng Xiao, Shuhua Xu, Jin Ok Yang, Yin Yao Shugart, Hyang Sook Yoo, Wentao Yuan, Guoping Zhao, Bin Alwi Zilfalil,

Race, Genetics, and Society

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.