Portal de Periódicos da CAPES

Protection against Anthrax Toxemia by Hexa- d -Arginine In Vitro and In Vivo

2003; American Society for Microbiology; Volume: 72; Issue: 1 Linguagem: Inglês

10.1128/iai.72.1.602-605.2004

1098-5522

Miroslav S. Sarač, Juan R. Peinado, Stephen H. Leppla, Iris Lindberg,

Microbial Inactivation Methods

ABSTRACT The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa- d -arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.