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Chromogranin A in heart failure. A novel neurohumoral factor and a predictor for mortality

2002; Oxford University Press; Volume: 23; Issue: 12 Linguagem: Inglês

10.1053/euhj.2001.2977

1522-9645

Claudio Ceconi, Roberto Ferrari, Tiziana Bachetti, Cristina Opasich, Maurizio Volterrani, Barbara Colombo, Gaspare Parrinello, Angelo Corti,

Calcium signaling and nucleotide metabolism

Background In chronic heart failure, several hormonal systems are activated with diagnostic and prognostic implications. We tested the hypotheses that serum Chromogranin-A (CgA)—a 49kDa acid protein present in the secretor granules of neuroendocrine cells—is increased in chronic heart failure and that CgA levels are a predictive factor for mortality.