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Helicobacter pylori Cytotoxin-Associated Genotype and Gastric Precancerous Lesions

2007; Oxford University Press; Volume: 99; Issue: 17 Linguagem: Inglês

10.1093/jnci/djm120

1460-2105

Martyn Plummer, L.J. van Doorn, Silvia Franceschi, B Kleter, Federico Canzian, Jorge Vivas, Gabriel P. López, D Colin, Núbia Muñóz, Ikuko Kato,

Eosinophilic Esophagitis

BackgroundHelicobacter pylori infection is associated with the development of gastric cancer. Although infection with an H. pylori strain containing the cytotoxin-associated (cag A) gene (a marker for a pathogenicity island) may increase the risk of atrophic gastritis and gastric cancer, the relationship of variants in pathogenic H. pylori genes to the severity and progression of precancerous lesions is not well defined.