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Physical Properties and Pharmacological Activity: Antihistaminics

1956; Elsevier BV; Volume: 45; Issue: 5 Linguagem: Inglês

10.1002/jps.3030450508

1930-2304

Nicholas G. Lordi, John E. Christian,

Chemical Thermodynamics and Molecular Structure

The ionization constants, solubilities, and relative surface activities of sixteen com-mercially available antihistaminics are reported. The antihistaminic effect is reviewed and discussed in the light of these properties. The usefulness of solubility as an indicator of toxicity, duration of effect, and local anesthetic potency is emphasized.