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Cilia are at the heart of vertebrate left–right asymmetry

2003; Elsevier BV; Volume: 13; Issue: 4 Linguagem: Inglês

10.1016/s0959-437x(03)00091-1

1879-0380

James McGrath, Martina Brueckner,

Protist diversity and phylogeny

Handed asymmetry of the shape and position of the internal organs is found in all vertebrates, and is essential for normal cardiac development. Recent genetic and embryological experiments in mouse embryos have demonstrated that left–right asymmetry is established by directional flow of extraembryonic fluid surrounding the node, which is driven by motile monocilia.